Comparative characterization of catalytic properties of mitochondrial and cytosolic forms of nad-dependent malate dehydrogenase from rats liver at norm and under toxic hepatitis

   


1. Voronezh State University, Biology and Soil Science Faculty, Department of Medical Biochemistry and Microbiology
Type: Experimental/clinical study
UDK: 577.152:616.36-002      PubMed Id: 20000126
Year: 2009 vol: 55  issue:4  pages: 489-499
Abstract: The purification and comparative characterization of some catalytic properties of liver mitochondrial and cytosolic NAD-dependent malate dehydrogenase (NAD-MDH; EC 1.1.1.37) from normal rats and rats with experimental toxic hepatitis (ETH) have been carried out. It has been found that there are some differences in catalytic and regulatory properties of liver NAD-MDH from control animals and rats with ETH. It has been shown that Fe2+ and Cu2+ ions inhibit the enzyme, and the inhibition degree is different at norm and under toxic hepatitis. Ca2+ ions insignificantly activate cytosolic NAD-MDH under pathology and do not influence the mitochondrial isoform.
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Reference: Mikhailova E.V., Popova T.N., Safonova O.A., Comparative characterization of catalytic properties of mitochondrial and cytosolic forms of nad-dependent malate dehydrogenase from rats liver at norm and under toxic hepatitis, Biomeditsinskaya khimiya, 2009, vol: 55(4), 489-499.
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