Correction of glutamine metabolism impairments in the operated liver with chronic hepatitis by hyperbaric oxygen

   


1. Voronezh State Medical Academy
Type: Experimental/clinical study
UDK: 616.36-002.-089-008:9:547.466.6      PubMed Id: 20000127
Year: 2009 vol: 55  issue:4  pages: 500-509
Abstract: Application of hyperbaric oxygenation (HBO, 3 ata, 1 session for 50 min per day) during the first three days after liver resection (LR, 15-20% from the organ mass) in animals with chronic toxic hepatitis (ССl4, 50%, 0,1 ml / per 100 g of body mass, subcutaneously, once in 2 days, 65 days) eliminates a deficit of glutamine and glutamate in an operated liver and prevents accumulation of the endogenic toxin, ammonia, caused by combined effects of ССl4 and LR. Thus hyperbaric oxygen modulates the effect of the LR on the activity of key enzymes of the glutamine metabolism in liver: glutamine synthetases (GS) and phosphate-dependent glutaminases (PDG). HBO enhanced and prolonged the LR effect of the GS activity and restricted analogous changes in PDG during an early (3 day) postoperative period and promoted a delayed transient stimulation in the late (7 day) postoperative period. In contrast to non-oxygenated animals with LR this was not accompanied by accumulation of ammonia and the decrease in glutamine concentration in the liver.
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Reference: Savilov P.N., Correction of glutamine metabolism impairments in the operated liver with chronic hepatitis by hyperbaric oxygen, Biomeditsinskaya khimiya, 2009, vol: 55(4), 500-509.
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