Anticonvulsants action as bioantioxidants under stress conditions


1. Institute of Problems of Chemical Physics, Russian Academy of Science
2. Research Institute of Cytology and Molecular Biology
Type: Experimental/clinical study
UDK: 577.151.04; 577.152.313      PubMed Id: 20000129
Year: 2009 vol: 55  issue:4  pages: 519-524
Abstract: The action of heterocyclic amides series (ethosuximide, phenytoin, primidone) on lipid peroxdation and membrane bound monoamine oxidases A and B under stress condition has been studied.The intraperitoneal injection of the drugs resulted in enhancement of SOD, decrease of brain malondialdehyde content and mitochondrial activity of monoamine oxidases A and B.
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Reference: Bogdanov G.N., Mishchenko D.V., Kotelnikova R.A., Frog E.S., Fajngold I.I., Tatjanenko L.V., Dobrohotova O.V., Nartsissov J.R., Anticonvulsants action as bioantioxidants under stress conditions, Biomeditsinskaya khimiya, 2009, vol: 55(4), 519-524.