1. Department of Medical Biochemistry and Microbiology, Biology and Soil Science Faculty, Voronezh State University 2. Department of Pharmaceutical Chemistry and Technology, Pharmaceutical Faculty, Voronezh State University
Abstract: The study of some guanidine derivatives influence on free radical oxidation intensity and aconitase activity during the development of brain ischemia-reperfusion at rats has been carried out. The biochemiluminescence parameters increasing at the brain pathology changed toward normal values under the influence of N-[4-(chlorbenzoyl)benztiazol-2-yl]guanidine, N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine. The aconitase specific activity decreased in brain and blood of animals with ischemia-reperfusion. Administration of guanidine derivatives during brain ischemia-reperfusion development increased aconitase specific activity. These results suggest that investigated substances can play a role of neuroprotectors, preventing free radical oxidation development.
Download PDF:
Reference: Makeeva А.V., Popova T.N., Slivkin A.I., Krylsky D.V., The influense of guanidine derivatives on free radical oxidation intensity and aconitase activity at development of brain ischemia-reperfusion at rats, Biomeditsinskaya khimiya, 2009, vol:
55(5), 643-650.
13. Крыльский Д.В., Шихалиев Х.С., Ковыгин Ю.А., Потапов А.Ю. (2006) Гетероциклические системы на основе производных гуанидина и его структурных аналогов, ВГУ, Воронеж. Scholar google search
14. Scheen A.J., Letiexhe M.R., Lefebvre P J. (1995) Diabet Metab Rev., 11, 69-80. Scholar google search
15. Edward P., Bach М., Wail M.H. (1967) Clin. Chem., 13, 314-325. Scholar google search
16. Стальная И.Д., Гаришвили И.Д. (1977) Современные методы в биохимии, Медицина, М, с. 66-68. Scholar google search
17. Guilbault G.G. (1976) Handbook of Enzymatic Methods of Analysis, New-York. Scholar google search
18. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. (1951) J. Biol. Chem., 193(1), 265-275. Scholar google search
19. Буреш Я., Бурешова О., Хьюстон Д.П. (1991) Методики и основные эксперименты по изучению мозга и поведения, Медицина, М. Scholar google search
20. Murakami K., Yoshino M. (1997) Biochem. Mol. Biol. Int., 41(3), 481-486. Scholar google search
21. Gardner P.R., Raineri J. (1995) J. Biol. Сhem., 270(22), 11399-13405. Scholar google search
