1. Department of Medical Biochemistry and Microbiology, Biology and Soil Science Faculty, Voronezh State University 2. Department of Pharmaceutical Chemistry and Technology, Pharmaceutical Faculty, Voronezh State University
Abstract: The study of some guanidine derivatives influence on free radical oxidation intensity and aconitase activity during the development of brain ischemia-reperfusion at rats has been carried out. The biochemiluminescence parameters increasing at the brain pathology changed toward normal values under the influence of N-[4-(chlorbenzoyl)benztiazol-2-yl]guanidine, N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine. The aconitase specific activity decreased in brain and blood of animals with ischemia-reperfusion. Administration of guanidine derivatives during brain ischemia-reperfusion development increased aconitase specific activity. These results suggest that investigated substances can play a role of neuroprotectors, preventing free radical oxidation development.
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Reference: Makeeva А.V., Popova T.N., Slivkin A.I., Krylsky D.V., The influense of guanidine derivatives on free radical oxidation intensity and aconitase activity at development of brain ischemia-reperfusion at rats, Biomeditsinskaya khimiya, 2009, vol: 55(5), 643-650.
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