Effects of thapsigargicin on Cа2+ movements in l1210 cells permeabilized with digitonin

   


1. Department of Biology, Science Faculty, Anadolu University
Type: Experimental/clinical study
UDK: 577. 17.049; 612.01.015.3      PubMed Id: 20017396
Year: 2009 vol: 55  issue:5  pages: 651-662
Abstract: The effect of Thapsigargicin (TGC), a non-phorbol ester type tumor promoter, on Ca2+ movements has been investigated using L1210 mouse lymphoma cells. Ca2+ release from intact and digitonin permeabilized cells was evaluated using Fura-2 and Fura-3. TGC like Thapsigargin (TG) has the ability to discharge the intracellular Ca2+ stores and to increase intracellular free Ca2+ concentrations. TGC in a concentration dependent manner (0.16-16 nM) also inhibited cell growth and this effect was at least partially reversed by arachidonate.
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Reference: Oztetik E., Effects of thapsigargicin on Cа2+ movements in l1210 cells permeabilized with digitonin, Biomeditsinskaya khimiya, 2009, vol: 55(5), 651-662.
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