Proteolytic activity of placenta with EPH-gestosis


1. Department of Biochemistry Penza State Pedagogic University, Penza State University
Type: Experimental/clinical study
UDK: 612.015      PubMed Id: 20017398
Year: 2009 vol: 55  issue:5  pages: 673-680
Abstract: Essential edema-proteinuria-hypertension (EPH) gestosis still represents an important obstetrical problem. We have investigated the activity of carboxypeptidase Н (CPН), phenylmethylsulfonyl fluoride inhibited carboxypeptidase (PMSF-CP), carboxypeptidase M (CPM) and angiotensin-converting enzyme (ACE), the main carboxypeptidases in human placenta under normal conditions and mild EPH-gestosis. Gestosis was accompanied by the decrease in activity of the enzymes involved into metabolism of regulatory peptides (ACE, CPH, PMSF-CP, CPM) compared with their activity in placenta under physiological pregnancy. Correlation analysis revealed positive correlation between placental CPH and CPM (r = 0.2735*) in EPH-gestosis. These findings suggest involvement of placental proteases into formation of compensatory-adaptive reactions in the fetoplacental complex at EPH-gestosis; the data obtained may be also employed for the development of methods of prophylaxis and corrections of metabolic impairments in pathology of pregnancy.
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Reference: Petrushova O.P., Gengin M.T., Smetanin V.A., Kuznetsova A.V., Proteolytic activity of placenta with EPH-gestosis, Biomeditsinskaya khimiya, 2009, vol: 55(5), 673-680.
This paper is also available as the English translation:10.1134/S1990750809030123