Dependence between mitochondrial creatine kinase activity and ATP level in the brain ischemia

   


1. Nizhnii Novgorod State Technical University
2. Nizhnii Novgorod State Academy of Medicine
Type: Experimental/clinical study
UDK: 576.2: 618.8.001.6 - 005.4:51      PubMed Id: 20469724
Year: 2009 vol: 55  issue:6  pages: 759-765
Abstract: The disturbances of blood circulation changes metabolism and energy reactions in the brain. The method of mathematical analysis is used for the study of the dependence between the activity mitochondrial creatine kinase (CK) and ATP level the brains of rats subjected to acute and chronic ischemia. A model describing this dependence under different conditions of the activity of organisms has been proposed. Thus it is possible to predict catalytic properties of CK based on ATP level.
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Reference: Moshkova A.N., Yerlykina E.I., Khvatova E.M., Dependence between mitochondrial creatine kinase activity and ATP level in the brain ischemia, Biomeditsinskaya khimiya, 2009, vol: 55(6), 759-765.
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