Regulation of thyroid and pituitary function by bacterial lipopolysaccharide

   


1. Institute of Human Morphology RAMS
2. Orekhovich Institute of Biomedical Chemistry of RAMS; Russian People`s Friendship University, Medical School, Department of Biochemistry
Type: Experimental/clinical study
DOI: 10.18097/pbmc20105602179      UDK: 616.441-008.64: 616.981.48      PubMed Id: 21341506
Year: 2010 vol: 56  issue:2  pages: 179-186
Abstract: Activation of toll-like receptors-4 by bacterial lipopolysaccharide downregulates pituitary and thyroid function. Besides decrease of thyroid-stimulating hormone secretion lipopolysaccharide affects secretion in follicular thyroid cells directly. The endotoxin partialy activates and inhibits different phases of follicular thyrocytes' secretion. Lipopolysaccharide enhances thyroglobulin synthesis and exocytosis into follicular lumen and supresses its resorbtion.It results in sharp drop of blood thyroxine concentration without decrease of deiodinases-mediated thiroxine to triiodothyronine conversion. Stimulation of the lipopolysaccharide-pretreated thyroid gland with thyroid-stimulating hormone increases resorbtion of thyroglobulin and thyroid hormone production. Combined stimulation of the thyroid gland increases protein bound thyroxine and triiodothyronine serum concentration unlike only TSH stimulation resulting in increase of free thyroid hormone levels. It also prooves that binding capacity of thyroid hormone serum transport proteins during nonthyroidal illness syndrome remains normal.
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Reference: Yaglova N.V., Berezov T.T., Regulation of thyroid and pituitary function by bacterial lipopolysaccharide, Biomeditsinskaya khimiya, 2010, vol: 56(2), 179-186.
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