Improvement of pharmacological values of the nifedipine by means of mechanochemical complexation with glycyrrhizic acid

   


1. Novosibirsk Institute of Organic Chemistry Siberian Branch of RAS
2. Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of RAS
Type: Experimental/clinical study
DOI: 10.18097/pbmc20105602187      UDK: 615.214:547.1/0121      PubMed Id: 21341507
Year: 2010 vol: 56  issue:2  pages: 187-194
Abstract: A new water-soluble form of the calcium blocker nifedipine (NF) with glycyrrhizic acid (GA) (with molecular ratio 1:4) has been obtained by mechanochemical synthesis. Its pharmacological advantages in comparison with nifedipine were determined. An effective dose of nifedipine in complex reduced to 10 times as compared to its therapeutic dose while high antihypertensive activity preservation and pleiotropic antiarhythmic activity enhancement. This new antihypertensive and antiarhythmic agent (complex of NF:GA = 1:4) is chemically stable and safe for parenteral administration.
Download PDF:
Reference: Tolstikova T.G., Khvostov M.V., Bryzgalov A.O., Dushkin A.V., Meteleva E.S., Improvement of pharmacological values of the nifedipine by means of mechanochemical complexation with glycyrrhizic acid, Biomeditsinskaya khimiya, 2010, vol: 56(2), 187-194.
Bibliography
 2016(Vol:62)
 2015(Vol:61)
 2014(Vol:60)
 2013(Vol:59)
 2012(Vol:58)
 2011(Vol:57)
 2010(Vol:56)
 2009(Vol:55)
 2008(Vol:54)
 2007(Vol:53)
 2006(Vol:52)
 2005(Vol:51)
 2004(Vol:50)
 2003(Vol:49)