Abstract: Fractions of copper-binding protein (CBP) specifically bound copper ions were extracted from the rat liver cell cytosole. These fractions of 10-14 kDa proteins are involved in specific pattern of intracellular distribution of copper ions. The imprinting effect of specific pattern of copper ions intracellular distribution has been found. The effect was detected 30 days after sequented injections of copper sulfate into the body. It was shown, that after primary injection of copper the ability of CBP to bind copper ions could increase tenfold, regardless of schemes of copper sulfate injection.
Reference: Bozhkov A.I., Sidorov V.I., Dlubovskaya V.L., Shevtsova M.Ya., Surov Yu.N., Appearance of the imprinting effect on the specific pattern of intracellular distribution of copper ions in the liver after exposure to high concentrations of copper sulfate, Biomeditsinskaya khimiya, 2010, vol: