The level of free radical oxidation products in heart and blood plasma by diabetes mellitus with chronic alcohol intoxication

   


1. Omsk State Medical Academy
Type: Experimental/clinical study
DOI: 10.18097/pbmc20105602257      UDK: 577.334:[616.379-008.64+613.81]      PubMed Id: 21341513
Year: 2010 vol: 56  issue:2  pages: 257-265
Abstract: The research results of level glycemia, contents of free radical oxidation products (thiobarbiturate-reactive substances, oxidized-modified proteins) in blood plasma and heart of diabetes mellitus rats with chronic alcohol intoxication are presented. It is shown, that at presence of a diabetes mellitus the chronic alcohol consumption does not change blood plasma levels of the oxidized-modified proteins, thiobarbiturate-reactive substances and glucose. However the contents of thiobarbiturate-reactive substances and oxidizing modification of proteins products in animals heart is more considerably increased at combination of the diabetes with chronic alcohol consumption, in comparison with changes at the diabetes mellitus outside of alcoholization and with changes at the isolated chronic alcohol influence. Found out alcohol-induced free radical processes hyperactivation in heart at the diabetes is capable to render additional injuring influence.
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Reference: Indutny A.V., Bykov D.E., Vysokogorsky V.E., The level of free radical oxidation products in heart and blood plasma by diabetes mellitus with chronic alcohol intoxication, Biomeditsinskaya khimiya, 2010, vol: 56(2), 257-265.
This paper is also available as the English translation:10.1134/S1990750809040064
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