Low doses x-ray irradiation influence on liver detoxication system in rats with transplanted guerin's carcinoma

   


1. Fedkovich Chernivtsy National University
Type: Experimental/clinical study
DOI: 10.18097/pbmc20105602266      UDK: 577.112+616-006.6+614.876      PubMed Id: 21341514
Year: 2010 vol: 56  issue:2  pages: 266-273
Abstract: The activity of detoxication enzymes in liver microsomal fraction of preliminary radiation-exposed rats was investigated. It was shown that preliminary organism exposure to radiation reduced cytochrome Р450 and glutathione-S-transferase activity in liver microsomal fraction in the latent and logarithmic phases of oncogenesis compared with the unirradiated rats with tumor.Low level of cytochrome Р450 activity can be caused by transition of microsomal cytochrome P450 in P420 inactive form.The preliminary radiation does not influence the enzyme activity of liver cytochrome P450 and glutathione-S-transferase on terminal stages of Guerin's carcinoma growth.
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Reference: Marchenko М.М., Kopylchuk G.P., Ketsa О.V., Low doses x-ray irradiation influence on liver detoxication system in rats with transplanted guerin's carcinoma, Biomeditsinskaya khimiya, 2010, vol: 56(2), 266-273.
This paper is also available as the English translation:10.1134/S1990750809040076
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