The antioxidant status at patients with a thyreotoxicosis syndrome at the combined therapy with epifamin

   


1. Voronezh State Medical Academy of N.N. Burdenko
2. Voronezh State University
Type: Experimental/clinical study
DOI: 10.18097/pbmc20105603397      UDK: 577.17:615.036      PubMed Id: 20695219
Year: 2010 vol: 56  issue:3  pages: 397-403
Abstract: The work purpose was research of degree of free-radical processes intensity and catalase activity in blood serum of patients with a thyreotoxicosis syndrome at traditional treatment and the combined therapy with epifamin. Patients (n=25) have been divided into 2 groups: the first group of patients - 12 persons who are on traditional treatment (antithyreoid drugs, β-adrenoblockers); the second group - 13 persons, are padding to basic therapy received epifamin on 1 tablet (10 mg) 3 times a day 10-15 minutes prior to meal within 7 days. Patients with thyreotoxicosis syndrome had an intensification of free-radical oxidation that was traced at measurement of biochemiluminescence parameters in blood serum. At the combined therapy with epifamin less expressed intensity of free-radical processes, and also increasing of the general antioxidant activity of an organism that did not descend at traditional treatment was observed. At carrying out of standard therapy of thyreotoxicosis syndrome, including application of antithyreoid drugs and β-adrenoblockers, catalase activity decreased, that unfavorable affected antioxidant potential of an organism. At the combined therapy with epifamin level of catalase activity, on the contrary, increased, that could influence positively on antioxidant protection of an organism.
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Reference: Popov S.S., Pashkov A.N., Zoloedov V.I., Popova T.N., Rakhmanova T.I., The antioxidant status at patients with a thyreotoxicosis syndrome at the combined therapy with epifamin, Biomeditsinskaya khimiya, 2010, vol: 56(3), 397-403.
This paper is also available as the English translation:10.1134/S199075081004013X
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