Study "structure-anti-arrhythmic activity" relationship of n-phenil acetamide derivatives and amides of aromatic carbonic acids

   


1. Bashkir State University
2. Institute of Organic Chemistry, Ufa Scientific Center of Russian Academy of Sciences
Type: Experimental/clinical study
DOI: 10.18097/pbmc20105604471      UDK: 544.165+615.22      PubMed Id: 21032897
Year: 2010 vol: 56  issue:4  pages: 471-479
Abstract: Using the computer system SARD-21 (Structure Activity Relationship & Design) structural features of high- and low-effective anti-arrhythmic agents have been recognized and the influence of these features on the anti-arrhythmic properties has been evaluated. This information has been used for generation of the model for prediction of anti-arrhythmic effectiveness of pharmaceutical preparations with the 82%-level of recognition by two methods. The recognized structural parameters may be successfully used for design of new highly effective anti-arrhythmic drugs, and also for modification of structures of known anti-arrhythmic drugs for the increase of effectiveness of their anti-arrhythmic action.
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Reference: Khairullina V.R., Tarasov G.P., Gerchikov A.Ja., Zarydiy F.S., Tjurina L.A., Study "structure-anti-arrhythmic activity" relationship of n-phenil acetamide derivatives and amides of aromatic carbonic acids, Biomeditsinskaya khimiya, 2010, vol: 56(4), 471-479.
This paper is also available as the English translation:10.1134/S1990750810020034
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