Abstract: Chronic parenteral administration of cobalt chloride (6 mg/kg) to male rats for 2 weeks or 1 month was accompanied by activation of lipid peroxidation (LPO), a decrease of superoxide dismutase activity and an increase of catalase activity. The membrane toxic action also resulted in a decrease of cortical and medullar Na+,K+-ATPase activity of kidneys, and the decrease in renal functions (glomerular filtration, renal water reabsorption, spontaneous diuresis, electrolyte excretion).
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Reference: Tedtoeva A.I., Dzugkoeva F.S., Mozhaeva I.V., Dzugkoev S.G., Lipid peroxidation, activity of Na+,K+-ATPase and exzymes of antioxidant defence in rats with nephropathy induced by cobalt chloride, Biomeditsinskaya khimiya, 2010, vol: 56(5), 540-544.
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