Lipid peroxidation, activity of Na+,K+-ATPase and exzymes of antioxidant defence in rats with nephropathy induced by cobalt chloride

   


1. Institute of Biomedical Studies, Vladikavkaz Scientific Center, Russian Academy of Science and Government of Republic Northern Osetia Alania
Type: Experimental/clinical study
DOI: 10.18097/pbmc20105605540      UDK: 577.352.3      PubMed Id: 21254623
Year: 2010 vol: 56  issue:5  pages: 540-544
Abstract: Chronic parenteral administration of cobalt chloride (6 mg/kg) to male rats for 2 weeks or 1 month was accompanied by activation of lipid peroxidation (LPO), a decrease of superoxide dismutase activity and an increase of catalase activity. The membrane toxic action also resulted in a decrease of cortical and medullar Na+,K+-ATPase activity of kidneys, and the decrease in renal functions (glomerular filtration, renal water reabsorption, spontaneous diuresis, electrolyte excretion).
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Reference: Tedtoeva A.I., Dzugkoeva F.S., Mozhaeva I.V., Dzugkoev S.G., Lipid peroxidation, activity of Na+,K+-ATPase and exzymes of antioxidant defence in rats with nephropathy induced by cobalt chloride, Biomeditsinskaya khimiya, 2010, vol: 56(5), 540-544.
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