Neuromediator systems in some brain regions of rats subjected to morphine intoxication

   


1. Grodno State Medical University
2. Institute of Biochemistry, Byelorussian Academy of Sciences
Type: Experimental/clinical study
DOI: 10.18097/pbmc20105605562      UDK: 547.015.+615.212.7.015.15.015.4.      PubMed Id: 21254626
Year: 2010 vol: 56  issue:5  pages: 562-569
Abstract: The content of neuromediators and its metabolites in the cortex of cerebral hemispheres, in thalamus and brain stem was studied under chronic morphine intoxication (7-21 days). The morphine intake during 7-14 days was accompanied by changes of catecholamine system functioning, which was the most pronounced in the thalamus and the brain stem. These changes included increased secretion of dophamine and noradrenaline, their decrease in the brain tissue, and the increased content of their metabolites. The changes of serotonin and GABA content were less pronounced and included a decrease of serotonin level and the increase of the GABA content in different periods of narcotization.
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Reference: Lelevich S.V., Novokshonov A.A., Neuromediator systems in some brain regions of rats subjected to morphine intoxication, Biomeditsinskaya khimiya, 2010, vol: 56(5), 562-569.
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