Formation and participation of nano-amyloids in pathogenesis of Alzheimer's disease and other amyloidogenic diseases

   


1. Russian Gerontological Research Clinical Center, Russian Ministry of Health Care Institute of Biological Instrumentation, Russian Academy of Sciences
2. Insitute of Protein Research, Russian Academy of Sciences, Pushchino
Type: Review
DOI: 10.18097/PBMC20105606624      UDK: 577.32.4.322+616.003.821+616.831      PubMed Id: 21395066
Year: 2010 vol: 56  issue:6  pages: 624-638
Abstract: Studies of neurodegenetrative disorders have become particularly actual attracting the attention of researchers from over the world because of the dissemination of Alzheimer's disease. The reason for such pathogenesis is the transition of a "healthy" molecule or peptide from the native conformation into a very stable "pathological" isoform. During this, molecules in the "pathological" conformation aggregate, forming amyloid fibrils that can increase without any control. Novel knowledge is required on sporadic isoforms of Alzheimer's disease, on the nature of triggering mechanisms of conformational transitions of beta-amyloid fragments from normally functioning proteins into new formations - nano-beta-amyloids - that spiral out of control of neurons and organism which leads to the loss of neurons. Herein we review studies devoted to the formation of amyloid fibrils and their role in pathogenesis of amyloid diseases.
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Reference: Maltsev A.V., Galzitskaya O.V., Formation and participation of nano-amyloids in pathogenesis of Alzheimer's disease and other amyloidogenic diseases, Biomeditsinskaya khimiya, 2010, vol: 56(6), 624-638.
This paper is also available as the English translation:10.1134/S1990750810030030
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