1. Russian Gerontological Research Clinical Center, Russian Ministry of Health Care
Institute of Biological Instrumentation, Russian Academy of Sciences 2. Insitute of Protein Research, Russian Academy of Sciences, Pushchino
Abstract: Studies of neurodegenetrative disorders have become particularly actual attracting the attention of researchers from over the world because of the dissemination of Alzheimer's disease. The reason for such pathogenesis is the transition of a "healthy" molecule or peptide from the native conformation into a very stable "pathological" isoform. During this, molecules in the "pathological" conformation aggregate, forming amyloid fibrils that can increase without any control. Novel knowledge is required on sporadic isoforms of Alzheimer's disease, on the nature of triggering mechanisms of conformational transitions of beta-amyloid fragments from normally functioning proteins into new formations - nano-beta-amyloids - that spiral out of control of neurons and organism which leads to the loss of neurons. Herein we review studies devoted to the formation of amyloid fibrils and their role in pathogenesis of amyloid diseases.
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Reference: Maltsev A.V., Galzitskaya O.V., Formation and participation of nano-amyloids in pathogenesis of Alzheimer's disease and other amyloidogenic diseases, Biomeditsinskaya khimiya, 2010, vol: 56(6), 624-638.
6. Figueredo-Pereira M.E., Efthimiopoulos S., Tezapsidis N., Buku A., Ghiso J., Mehta P., Robakis N.K. (1999) J. Neurochem., 72(4), 1417-1422. . CrossRef Scholar google search
7. Shoji M., Golde T.E., Ghiso J., Cheung T.T., Estus S., Shaffer L.M., Cai X.D., McKay D.M., Tintner R., Frangione B., Younkin S.G. (1992) Science, 258(5079), 126-129. . CrossRef Scholar google search
8. Sokolik V.V., Maltzev A.V. (2008) Fourth International Interdisciplinary Congress "Neuroscience for Medicine and Psychology", Sudak, Crimea, Ucraine. June 10-20, pp. 278-280. . Scholar google search
9. Maddalena A.S., Papassotiropoulos A., Gonzalez-Agosti C., Signorell A., Hegi T., Pasch T., Nitsch R.M., Hohk C. (2004) Neurodegener. Dis., 1(4-5), 231-235. . CrossRef Scholar google search
10. Ghiso J., Shayo M., Calero M., Ng D., Tomidokoro Y., Gandy S., Rostagno A., Frangione B. (2004) J. Biol. Chem., 279(44), 45897-45908. . CrossRef Scholar google search
16. Sprecher C.A., Grant F.J., Grimm G., O`Hara P.J., Norris R., Foster D.S. (1993) Biochemistry, 32(17), 4481-4486. . CrossRef Scholar google search
17. Fardilha M., Vieira S.I., Barros A., Sousa M., Da Cruz e Silva O.A., Da Cruz e Silva E.F. (2007) Ann. N.Y. Acad. Sci., 1096, 196-206. . CrossRef Scholar google search
18. Arai H., Lee V.M., Messinger M.L., Greenberg B.D., Lowery D.E., Trijanowski J.Q. (1991) Ann. Neurol., 30(5), 686-693. . CrossRef Scholar google search
19. Roher A.E., Lowenson J.D., Clarke S., Woods A.S., Cotter R.J., Gowing E., Ball M.J. (1993) Proc. Natl. Acad. Sci. USA., 90(22), 10836-10840. . CrossRef Scholar google search
20. Vigo-Pelfrey C., Lee D., Keim P., Lieberburg I., Schenk D.B. (1993) J. Neurochem., 61(5), 1965-1968. . CrossRef Scholar google search
21. Liu T., Qian W.-J., Gritsenko M.A., Camp D.G., Monroe M.E., Move R.J., Smith R.D. (2005) J. Proteome Res., 4(6), 2070-2080. . CrossRef Scholar google search
22. Van Nostrand W.E., Cunningham D.D. (1987) J. Biol. Chem., 262(18), 8508-8514. . Scholar google search
23. Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerhove J. (2003) Nat. Biotechnol., 21(5), 566-569. . CrossRef Scholar google search
24. Konig G., Monning U., Czech C., Prior R., Banati R., Schreiter-Gasser U., Bauer J., Masters C.L., Beyreuther K. (1992) J. Biol. Chem., 267(15), 10804-10809. . Scholar google search
25. Gelfanova V., Higgs R.E., Dean R.A., Holtzman D.M., Farlow M.R., Siemers E.R., Boodhoo A., Qian Y.W., He X., Jin Z., Fisher D.L., Cox K.L., Hale J.E. (2007) Breefings in Functional Genomics and Proteomics, 6(2), 149-158. . CrossRef Scholar google search
35. Kaminskij Yu.G., Kosenko E.А., Venediktova N.I., Mal'tsev А.V. (2003) V sb. konferentsii: Fundamental'nye nauki - meditsine. RАN, Moskva, pp. 8-10. Scholar google search
36. Mal'tsev А.V., Kaminskij Yu.G., Bobkova N.V., Budantsev А.Yu., Gavrilova S.I. (2004) V al'manakhe: Gerontologiya i geriatriya. Vyp. 3, pp. 96-101. Scholar google search
37. Ling G. (2008) Fizicheskaya teoriya zhivoj kletki. Nezamechennaya revolyutsiya. Sankt Peterburg. Scholar google search
39. Chen Y.R., Huang H.B., Chyan C.L., Shiao M.S., Lin T.H., Chen Y.C. (2006) J. Biochem., 139(4), 733-740. . CrossRef Scholar google search
40. Ma Q.F., Hu J., Wu W.H., Liu H.D., Du J.T., Fu Y., Wu Y.W., Lei P., Zhao Y.F., Li Y.M. (2006) Biopolymers, 83(1), 20-31. . CrossRef Scholar google search
41. Minicozzi V., Stellato F., Comai M., Serra M.D., Potrich C., Meyer-Klaucke W., Morante S. (2008) J. Biol. Chem., 283(16), 10784-10792. . CrossRef Scholar google search
42. Gulyaeva N.V. (2005) V sb. nauchnoj konferentsii: Nejrokhimiya: fundamental'nye i prikladnye aspekty. RАN, Moskva, ss. 163-163. Scholar google search
43. Singh N., Talalayeva Y., Tsiper M., Romanov V., Dranovsky A., Colflesh D., Rudamen G., Vitek M.P., Shen J., Yang X., Goldgaber D., Schwarzman A.L. (2001) Exp. Cell Res., 263(1), 1-13. . CrossRef Scholar google search
44. Mal'tsev А.V. (2008) Mezhdunarodnyj simpozium: Biologicheskie mekhanizmy stareniya. KHar'kov, Ukraina, pp 68-69. Scholar google search
45. Mal'tsev А.V., Mironova G.D., Bajramov V.M. (2008) Official Newsletter of the Federal Service for Intellectual Property Patent and Trademark Office "Inventions, utility models", № 16. Ru.2006141527.A. Scholar google search
46. Chiti F., Webster P., Taddei N., Clark A., Stefani M., Ramponi G., Dobson C.M. (1999) Proc. Natl. Acad. Sci. USA, 96(7), 3590-3594. . CrossRef Scholar google search
47. Dobson C.M. (2009) International bunsen discussion meeting on structure of amyloid fibrils and mechanism of amyloid formation, Halle, Germany, p. 12. . Scholar google search
48. Dobson C.M. (1999) Protein misfolding, evolution and disease. Trends Biochem. Sci., 24(9), 329-332. . CrossRef Scholar google search
49. Fandrich M., Fletcher M.A., Dobson C.M. (2001) Nature, 410(6825), 165-166. . Scholar google search
50. Bucciantini M., Calloni G., Chiti F., Formigli L., Nosi D., Dobson C.M., Stefani M. (2004) J. Biol. Chem., 279(30), 31374-31382. . CrossRef Scholar google search
51. Kayed R., Head E., Thompson J.L., McIntire T.M., Milton S.C., Cotman C.W., Glabe C.G. (2003) Science, 300(5618), 486-489. . CrossRef Scholar google search
54. Tenidis K., Waldner M., Bernhagen J., Fischle W., Bergmann M., Weber M., Merkle M.L., Voelter W., Brunner H., Kapurniotu A. (2000) J. Mol. Biol., 295(4), 1055-1071. . CrossRef Scholar google search
55. von Bergen M., Friedhoff P., Biernat J., Heberle J., Mandelkow E.M., Mandelkow E. (2000) Proc. Natl. Acad. Sci. USA, 97(10), 5129-5134. . CrossRef Scholar google search
56. Ivanova M.I., Sawaya M.R., Gingery M., Attinger A., Eisenberg D. (2004) Proc. Natl. Acad. Sci. USA, 101(29), 10584-10589. . CrossRef Scholar google search
57. Esteras-Chopo A., Serrano L., Lopez de la Paz M. (2005) Proc. Natl. Acad. Sci. USA, 102(46), 16672-16677. . CrossRef Scholar google search
58. Pawar A.P., Dubay K.F., Zurbo J., Chiti F., Vendruscol K., Dobson C.M. (2005) J. Mol. Biol., 350, 379-392. . Scholar google search
59. Chiti F., Stefani M., Taddei N., Ramponi G., Dobson C.M. (2003) Nature, 424, 808. . Scholar google search
60. Chiti F., Taddei N.,Bucciantini M., White P., Ramponi G., Dobson C.M. (2000) EMBO J., 19(7), 1441-1449. . Scholar google search
76. Nelson R., Sawaya M.R., Balbirnie M., Madsen A.O., Riekel C. et al. (2005) Nature, 435, 747-749. . CrossRef Scholar google search
77. Luhrs T., Ritter C., Adrian M., Riek-Loher D., Bohrmann B., Dobeli H., Schubert D., Riek R. (2005) Proc. Natl. Acad. Sci. USA, 102(48), 17342-17347. . CrossRef Scholar google search
