Synthetic peptide vaccines


1. Institute of Biomedical Chemistry, Russian Academy of Medical sciences
Type: Review
DOI: 10.18097/pbmc20115701104      UDK: 571.27:615.281:547.96      PubMed Id: 21516776
Year: 2011 vol: 57  issue:1  pages: 14-30
Abstract: This review considers the stages of the development of synthetic peptide vaccines against infectious agents, novel approaches and technologies employed in this process, including bioinformatics, genomics, proteomics, large-scale peptide synthesis, high-throughput screening methods, the use of transgenic animals for modelling human infections. An important role for the development and selection of efficient adjuvants for peptide immunogens is noted. Examples of synthetic peptide vaccine developments against three infectious diseases (malaria, hepatitis C, and foot-and-mouth disease) are given.
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Reference: Moysa A.A., Kolesanova E.F., Synthetic peptide vaccines, Biomeditsinskaya khimiya, 2011, vol: 57(1), 14-30.
This paper is also available as the English translation:10.1134/S1990750810040025