Implication of integrin α5β1 in human breast carcinoma apoptosis and drug resistance

   


1. Institute of Biomedical Chemistry, Russian Academy of Medical Sciences
Type: Experimental/clinical study
DOI: 10.18097/pbmc20115701077      UDK: 577.385.5      PubMed Id: 21516779
Year: 2011 vol: 57  issue:1  pages: 77-84
Abstract: Doxorubicin-resistant MCF-7Dox line, which is a derivative of the drug-sensitive MCF-7 human breast carcinima line, differs from the latter by a strongly reduced expression of the α2β1 integrin and a highly increased expression of the α5β1 receptor. Silencing of this integrin in the MCF-7Dox cells by transfection with α5-specific siRNA markedly stimulated anoikis and increased sensitivity of the cells to doxorubicin. α5β1 silencing also leads to significant inhibition of the activity of kinases Akt and Erk2 in MCF-7Dox cells. Our results suggest that integrins α5β1-induced signals, controlling distinct aspects of cell behavior, are conducted through the common signal pathways.
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Reference: Morozevich G.E., Kozlova N.I., Ushakova N.A., Preobrazhenskaya M.E., Berman A.E., Implication of integrin α5β1 in human breast carcinoma apoptosis and drug resistance, Biomeditsinskaya khimiya, 2011, vol: 57(1), 77-84.
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