Abstract: Some exometabolites produced by basic representatives of human anaerobic microflora were investigated, detected by gas chromatography - mass spectrometry (GC-MS). In vitro besides lactic acid Bifidobacterium and Lactobacillus generate substantial amounts of phenyllactic and p-hydroxyphenyllactic acids. Clostridium produced 2-hydroxybutyric acid and to a lesser extent lactic and phenyllactic acids. In contrast to С. perfringens, C. sporogenes generates substantial amount of phenylpropionic and p-hydroxyphenylpropionic acids and less p-hydroxyphenyllactic acid. С. perfringens produced minor amounts of 2-hydroxyglutaric acid. Bacteroids are potent producers of succinic and fumaric acids; they also contribute to production of significant portion of lactic acid. E. lentum generate lactic, phenyllactic and succinic acids and form a characteristic only for ones (from studied microorganisms) 2-hydroxyhexanic and 2-hydroxy-3-methylbutyric acids.
Reference: Beloborodova N.V., Bairamov I.T., Olenin A.Yu., Fedotcheva N.I., Exometabolites of some anaerobic microorganisms of human microflora, Biomeditsinskaya khimiya, 2011, vol:
1. Beloborodova N.V., Beloborodov S.M. (2000) Аntibiotiki i khimioterapiya, 45, 28-36. Scholar google search
2. Larsen B. (1993) Normal Flora and Endogenous Infection. in: Obstetric and perinatal infections (ed. D.Charles) Mosby-Year Book, pp. 3-9. Scholar google search
3. Eftimiadi C., Tonetti M., Cavallero A., Sacco O., Rossi G.A. (1990) J. Infect. Dis., 161, 138-142. Scholar google search