Exometabolites of some anaerobic microorganisms of human microflora


1. Bakoulev Center for Cardiovascular Surgery RAMS
2. Institute of Theoretical and Experimental Biophysics, RAS
Type: Experimental/clinical study
DOI: 10.18097/pbmc20115701095      UDK: 579.222.3      PubMed Id: 21516781
Year: 2011 vol: 57  issue:1  pages: 95-105
Abstract: Some exometabolites produced by basic representatives of human anaerobic microflora were investigated, detected by gas chromatography - mass spectrometry (GC-MS). In vitro besides lactic acid Bifidobacterium and Lactobacillus generate substantial amounts of phenyllactic and p-hydroxyphenyllactic acids. Clostridium produced 2-hydroxybutyric acid and to a lesser extent lactic and phenyllactic acids. In contrast to С. perfringens, C. sporogenes generates substantial amount of phenylpropionic and p-hydroxyphenylpropionic acids and less p-hydroxyphenyllactic acid. С. perfringens produced minor amounts of 2-hydroxyglutaric acid. Bacteroids are potent producers of succinic and fumaric acids; they also contribute to production of significant portion of lactic acid. E. lentum generate lactic, phenyllactic and succinic acids and form a characteristic only for ones (from studied microorganisms) 2-hydroxyhexanic and 2-hydroxy-3-methylbutyric acids.
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Reference: Beloborodova N.V., Bairamov I.T., Olenin A.Yu., Fedotcheva N.I., Exometabolites of some anaerobic microorganisms of human microflora, Biomeditsinskaya khimiya, 2011, vol: 57(1), 95-105.