Accumulation of porphyrins in cells of system of blood induced by 5-aminolаevulinic acid

   


1. The Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Type: Experimental/clinical study
DOI: 10.18097/pbmc20115702195      UDK: 577.112.3:612.41/.42.086.164      PubMed Id: 21870605
Year: 2011 vol: 57  issue:2  pages: 195-200
Abstract: The levels and rates of accumulation of porphyrins in lymphoid cells and bone marrow cells treated with exogenous 5-aminolaevulinic acid (ALA) were studied. The dependence of the quantity of porphyrins accumulated in cell on ALA concentrations in the medium had maximum at 0.7-1.0 mM ALA for all the cell types studied (splenocytes, thymocytes, peripheral blood lymphocytes and bone marrow cells). The rate of accumulation of uro-, copro- and protoporphyrins depended on cell types. The lowest and the highest levels were found in splenocytes and highest in bone marrow cells respectively. It is suggested that photodynamic therapy employing ALA is potentially dangerous for blood cells.
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Reference: Lobanok Е.С., Vasilevich I.B., Vorobey A.V., Accumulation of porphyrins in cells of system of blood induced by 5-aminolаevulinic acid, Biomeditsinskaya khimiya, 2011, vol: 57(2), 195-200.
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