Influence of α-lipoic acid on liver glutathione system of healthy and ehrlich ascites carcinoma transplanted mice

   


1. Irkutsk state medical university
Type: Experimental/clinical study
DOI: 10.18097/pbmc20115702219      UDK: 615.015.3:577.12:616-006.6      PubMed Id: 21870608
Year: 2011 vol: 57  issue:2  pages: 219-224
Abstract: Influence of α-lipoic acid (LA) on liver glutathione system of Ehrlich ascites carcinoma (EAC) transplanted mice was studied. LA causes multidirectional influence on glutathione system of healthy mice. EAC transforms LA influence, strengthening prooxidative effects more expressed at introduction in early terms after inoculation of the tumor. The mechanism explaining realization of LA prooxidative effects as a result of interaction with glutathione system is suggested.
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Reference: Kolesnichenko L.S., Laletin V.S., Kulinsky V.I., Influence of α-lipoic acid on liver glutathione system of healthy and ehrlich ascites carcinoma transplanted mice, Biomeditsinskaya khimiya, 2011, vol: 57(2), 219-224.
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