The analysis of interaction between lipoproteins and steroid hormones


1. Institute of Biochemistry, Siberian Division, Russian Academy of Medical Science
Type: Experimental/clinical study
DOI: 10.18097/pbmc20115703308      UDK: 577.112.856:612.621/616.31      PubMed Id: 21863744
Year: 2011 vol: 57  issue:3  pages: 308-313
Abstract: Using the methods of ultracentrifugation, gel-filtration and fluorescence quenching, we demonstrated, that plasma lipoproteins bind steroid hormones and can therefore play a role of their active transport form in an organism. High density lipoproteins have revealed the highest affinity to steroids for. It has been found, that protein component of lipoproteins takes part in the formation of lipoprotein-steroid complex. The apolipoprotein A-I, the main protein component of high density lipoproteins, is responsible for binding of steroid hormones. The calculated constants formation of the complexes of lipoproteins with steroid hormones testifies to specificity of linkage. The results obtained allow to considering real opportunity of transfer of steroid hormones into cell by a receptor-mediated endocytosis in structure of lipoproteins complexes.
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Reference: Polyakov L.M., Sumenkova D.V., Knyazev R.A., Panin L.E., The analysis of interaction between lipoproteins and steroid hormones, Biomeditsinskaya khimiya, 2011, vol: 57(3), 308-313.
This paper is also available as the English translation:10.1134/S1990750810040062