The comparative study of the medical action of lyuteolin, rosmarinic acid and echinochrom A at experimental stress-induced cardiopathology

   


1. Far Eastern National University
2. Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Science
Type: Experimental/clinical study
DOI: 10.18097/pbmc20115703314      UDK: 76.03.31, 616-092.9, 616-03, 616-091.8, 577.125.8, 57.017.3      PubMed Id: 21863745
Year: 2011 vol: 57  issue:3  pages: 314-325
Abstract: The method of the physical load in condition of the coronary circulation of the blood disturbance, caused mesaton injection, induced development rat cardiopathology, bring about of the heart function decompensation and 40% death of experimenthal animals. Under electronic-microscopic study of rat cardiomyocytes are discovered signs to disorganizations of mitochondrial apparatus of these cells. Administration to therapeutic mode of luteolin and echinochrome A preparations has provided to 100% animal probability of survival. At the same time, mitochondrial apparatus of cardiomyocytes was characterized by the normal parameter i.e. given preparations have provided of defensive adative effect at cardiomyocytes level. Similar activities for rosmarinic acid have not shown. Study some metabolic parameter and endocrine status animal has also allowed revealing of therapeutic effect of luteolin and echinochrome A.Findings be evidence of that echinochrome А and luteolin capable to play the important positive role in metabolism of cardiomyocytes by stimulating of mitochondrial biogenesis and by changing of adaptative mechanisms of the organism cardiovascular system protection.
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Reference: Tsybulsky A.V., Popov A.M., Artyukov A.A., Kostetsky E.Y., Krivoshapko O.N., Maseyka A.N., Kozlovskaya E.P., The comparative study of the medical action of lyuteolin, rosmarinic acid and echinochrom A at experimental stress-induced cardiopathology, Biomeditsinskaya khimiya, 2011, vol: 57(3), 314-325.
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