Evaluation of cytotocicity and efficiency of antioxidant protection of hydrophilic derivatives of 2,4,6-trialkylphenols in escherichia coli cells

   


1. Institute of Cytology and Genetics, SD RAS
2. Novosibirsk State Pedagogic University
3. Institute of Cytology and Genetics, SD RAS SD RAS Institute of Chemical Biology and Fundamental Medicine
Type: Experimental/clinical study
DOI: 10.18097/pbmc20115703326      UDK: 547.563;379.3.057      PubMed Id: 21863746
Year: 2011 vol: 57  issue:3  pages: 326-334
Abstract: The effects of five new derivatives of 2,6-dialkyl-4-propylphenole containing in para-radical different ionogenic groups (-SO3Na, -S-SO3Na, -S-(NH2)2Cl) in the presence and in the absence of hydrogen peroxide on the survival of E. coli AB1157 cells and its isogenic strain defective in repair enzyme genes were studied. Cell survival treated with hydrogen peroxide was remarkably increased in the presence of (3-(3,5-dimethyl-4-hydroxyphenyl)propyl)-1-sulphonate of sodium (С1). Replacement of methyl оrtho-radicals in the structure of С1 for tret-buthyl or cyclohexyl groups led to a decrease of the compounds ability to protect the cells from exogenic hydrogen peroxide. Between derivatives of 2,6-di-tret-buthylphenol the compound with thiosulphonate group demonstrated properties comparable with those for its sulphonate analog, then a chloride of isotiurone at concentration 3 mM completely suppressed the growth of cells in presence and in the absence of Н2О2. Compound C1 may be considered as most perspective for detail analysis as antioxidant.
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Reference: Rotskaya U.N., Ovchinnikova L.P., Vasunina Е.А., Sinitsina О.I., Kandalintseva N.V., Prosenko Е.А., Nevinsky G.А., Evaluation of cytotocicity and efficiency of antioxidant protection of hydrophilic derivatives of 2,4,6-trialkylphenols in escherichia coli cells, Biomeditsinskaya khimiya, 2011, vol: 57(3), 326-334.
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