Study of Dj-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients

   


1. A.N. Bach Institute of Biochemistry, Russian Academy of Medical Sciences
2. Russian Medical Academy of Postgraduate Education
3. Institute of Biomedical Chemistry, Russian Academy of Medical Sciences
Type: Experimental/clinical study
DOI: 10.18097/pbmc20115704392      UDK: 577.122: 616.65-006-07      PubMed Id: 22066264
Year: 2011 vol: 57  issue:4  pages: 392-401
Abstract: Two isoforms of Dj-1 protein were identified using a proteomic study in tissue specimens from two groups of patients with confirmed benign prostate hyperplasia (BPH) and prostate cancer (PCa). Dj-1 was also found in the cell lines РС-3, DU-145, LNCaP, BPH-1, and the lowest level of Dj-1 was found in BPH-1. Immunochemical study (ELISA) of serum levels of Dj-1, Bcl-2, IGF-1 and IGFBP-3 proteins revealed statistically significant distinctions between two groups of patients (р=0,004, Mann-Whitney test) only for Dj-1. Taken together, these data suggest that Dj-1 protein is a perspective biomarker candidate for PCa.
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Reference: Lisitskaya K.V., Eremina L.S., Ivanov A.V., Kovalyova M.A., Okhrits V.E., Toropygin I.Y., Kovalyov L.I., Shishkin S.S., Study of Dj-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients, Biomeditsinskaya khimiya, 2011, vol: 57(4), 392-401.
This paper is also available as the English translation:10.1134/S1990750811010070
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