Abstract: The content of cytokines, and gangliosides metabolism, and the quantity of lipid peroxidation products were studied at experimental brain edema. Data obtained show increase the level of proinflammatory cytokins and decrease the level of antiinflammatory cytokines during development of brain edema. Along with this we reveal the accumulation of lipid peroxidation products (diene conjugates, hydroperoxides, and malonic dialdehyde). Each fraction of gangliosides decreased, but the product of their hydrolytic dissociation sphingosine increased at experimental brain edema.
Reference: Zakaryan A.V., Kazaryan G.S., Zakaryan G.V., Melkonyan M.M., Hovsepyan L.M., Study of cytokines content and gangliosides metabolism at experimental brain edema, Biomeditsinskaya khimiya, 2011, vol: