The influence of compound itel1296 on telomerase activity and the growth of cancer cells

   


1. I.M. Sechenov First Moscow State Medical University, Research Center
2. Institute of Biomedical Chemistry of Russian Academy of Medical Sciences Peoples` Friendship University of Russia, Ecological Faculty
3. National Research Center of Antibiotics
Type: Experimental/clinical study
DOI: 10.18097/PBMC20115705501      UDK: 615.014.23.417      PubMed Id: 22629600
Year: 2011 vol: 57  issue:5  pages: 501-510
Abstract: Telomerase is a ribonucleoprotein that synthesizes telomeric repeats and identified as a promising target for anticancer therapy. Here we describe a new compound aITEL1296 as a potent telomerase inhibitor. Its inhibitory activity was a bit higher (IC50 = 0,19±0,02 ng/ml) than that of BIBR1532, one of the most potent telomerase inhibitors known to date. Besides telomerase inhibition aITEL1296 activated apoptotic mechanisms and effectively suppressed proliferation of tumor cell lines (GI50 = 5,0±0,2 ng/ml for most sensitive cell line LnCap) but not normal fibroblast cell line.
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Reference: Kovalenko N.A., Zhdanov D.D., Bibikova M.V., Gotovtseva V.Y., The influence of compound itel1296 on telomerase activity and the growth of cancer cells, Biomeditsinskaya khimiya, 2011, vol: 57(5), 501-510.
This paper is also available as the English translation:10.1134/S1990750812010064
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