1. I.M. Sechenov First Moscow State Medical University, Research Center 2. Institute of Biomedical Chemistry of Russian Academy of Medical Sciences
Peoples` Friendship University of Russia, Ecological Faculty 3. National Research Center of Antibiotics
Abstract: Telomerase is a ribonucleoprotein that synthesizes telomeric repeats and identified as a promising target for anticancer therapy. Here we describe a new compound aITEL1296 as a potent telomerase inhibitor. Its inhibitory activity was a bit higher (IC50 = 0,19±0,02 ng/ml) than that of BIBR1532, one of the most potent telomerase inhibitors known to date. Besides telomerase inhibition aITEL1296 activated apoptotic mechanisms and effectively suppressed proliferation of tumor cell lines (GI50 = 5,0±0,2 ng/ml for most sensitive cell line LnCap) but not normal fibroblast cell line.
Reference: Kovalenko N.A., Zhdanov D.D., Bibikova M.V., Gotovtseva V.Y., The influence of compound itel1296 on telomerase activity and the growth of cancer cells, Biomeditsinskaya khimiya, 2011, vol: