Abstract: The influence of some guanidine derivatives on the level of brain citrate, brain activities of aconitase and citrate synthase has been investigated in rats subjected to ischemia-reperfusion. Administration of N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine resulted in changes of specific activities of aconitase and citrate synthase towards control values. Under these conditions the citrate level considerably decreased versus rats with untreated ishemia-reperfusion. Treatment with these compounds also decreased the degree of DNA fragmentation markedly increased in rats with ischemia-reperfusion.
Reference: Sukhoveeva O.V., Popova T.N., Makeeva A.V., Iskusnykh I.Yu., The influence of n-[imino(1-piperidinyl)methyl]guanidine and n-[imino(4-morpholinyl)methyl]guanidine on citrate content,aconitase and citrate synthase activities at ischemia-reperfusionof rats brain, Biomeditsinskaya khimiya, 2011, vol: