Comparative feature of the glucose metabolism in liver of the rats under acute alcohol and morphine intoxication

   


1. Grodno medical state university
Type: Experimental/clinical study
DOI: 10.18097/pbmc20115706615      UDK: 547.262+615.217.7]:612.396.32:616.36.092]-092.9      PubMed Id: 22359917
Year: 2011 vol: 57  issue:6  pages: 615-623
Abstract: The comparative analysis effect of acute alcohol and morphine intoxications on rats on hepatic glycolysis and pentose phosphate pathway was done. The dose-dependent inhibitory effect of ethanol on activity of limiting enzymes of these metabolic ways, as well as anaerobic reorientation of glucose metabolism was recognised with the increase of the dose of the intake alcohol. Morfine (10 mg/kg) activated enymes of glycolysis and pentose phosphate pathway, but in contrast to ethanol it did not influence these parameters at the dose 20 or 40 mg/kg.
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Reference: Lelevich S.V., Comparative feature of the glucose metabolism in liver of the rats under acute alcohol and morphine intoxication, Biomeditsinskaya khimiya, 2011, vol: 57(6), 615-623.
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