Particularities of сorrective action of polar lipids and bioantioxidants from sea hydrobionts at imbalances of lipid and carbohydrate metabolism

   


1. Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Science
2. Far East State University
Type: Experimental/clinical study
DOI: 10.18097/pbmc20125802189      UDK: 577.12+615.324.593.96      PubMed Id: 22724358
Year: 2012 vol: 58  issue:2  pages: 189-198
Abstract: A total mixture of phospho- and glycolipids from sea macrophytes Sargassum pallidum, Ulva fenestrata, Zostera marina was separated and the fatty acid composition was determined. Biological activity of the mixtures of polar lipids and natural antioxidants echinochrome A from flat sea urchin Scaphechinus mirabilis and polyphenolic complex from sea grass Zostera marina was studied in rats with experimental model of atherosclerosis and diabetes. These experiments revealed optimal compositions for mixtures of polar lipids and antioxidants, which possess high medical-corrective activity. Proposed mechanisms of action of the polar lipids (containing different polyunsaturated fatty acids) and antioxidants studied are presented. These compositions may be used for creation of new biologically-active additives and drugs.
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Reference: Krivoshapko O.N., Popov А.М., Artyukov А.А., Kostetsky E.Y., Particularities of сorrective action of polar lipids and bioantioxidants from sea hydrobionts at imbalances of lipid and carbohydrate metabolism, Biomeditsinskaya khimiya, 2012, vol: 58(2), 189-198.
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