Mechanisms of anti-cancer effects of plant polyphenols II. Suppression on tumor growth

   


1. Research Institute of Pharmacology, Volgograd State Medical University
Type: Review
DOI: 10.18097/pbmc20125803257      UDK: 616-006.6      PubMed Id: 22856131
Year: 2012 vol: 58  issue:3  pages: 257-271
Abstract: Mechanisms of suppression of carcinogenesis promotion/progression by plant polyphenols have been considered. They can decrease cyclins and cycline dependent kinases and activate inhibitor proteins in tumor cells that results in cell cycle arrest. Plant polyphenols can induce apoptosis by modulating anti/proapoptotic proteins and also can inhibit tumor metastasis and angiogenesis. Polyphenols act through the regulation of cell signal transduction and gene expression.
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Reference: Zinov'eva V.N., Spasov A.A., Mechanisms of anti-cancer effects of plant polyphenols II. Suppression on tumor growth, Biomeditsinskaya khimiya, 2012, vol: 58(3), 257-271.
This paper is also available as the English translation:10.1134/S1990750811030164
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