Manganese in atherogenesis: detection, origin, and role


1. Kazan State University
2. Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center of RAS
3. Interregional Clinical Diagnostic Center
Type: Experimental/clinical study
DOI: 10.18097/pbmc20125803291      UDK: 577.15, 577.29, 577.151.33      PubMed Id: 22856134
Year: 2012 vol: 58  issue:3  pages: 291-299
Abstract: The role of transition metal ions in atherogenesis is controversial; they can participate in the hydroxyl radical generation and catalyze the reactive oxygen species neutralization reaction as cofactors of antioxidant enzymes. Using EPR spectroscopy, we revealed that 70% of the samples of aorta with atherosclerotic lesions possessed superoxide dismutase activity, 100% of the samples initiated Fenton reaction and demonstrated the presence of manganese paramagnetic centers. The sodA gene encoding manganese-dependent bacterial superoxide dismutase was not found in the samples of atherosclerotic plaques by PCR using degenerate primers. The data obtained indicates the perspectives of manganese analysis as a marker element in the express diagnostics of atherosclerosis.
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Reference: Lozhkin A.P., Biktagirov T.B., Gorshkiv O.V., Timonina E.V., Mamin G.V., Orlinskii S.B., Silkin N.I., Chernov V.M., Khairullin R.N., Salakhov M.Kh., Ilinskaya O.N., Abdul'yanov V.A., Manganese in atherogenesis: detection, origin, and role, Biomeditsinskaya khimiya, 2012, vol: 58(3), 291-299.
This paper is also available as the English translation:10.1134/S1990750811020090
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