Macroglobulin signaling system

   


1. Postgraduate Medical Training Institute, Central Research Laboratory
Type: Review
DOI: 10.18097/pbmc20125804400      UDK: 577:546.57.052      PubMed Id: 23413684
Year: 2012 vol: 58  issue:4  pages: 400-410
Abstract: This review will focus on the systematization of knowledge about structure of macroglobulin signaling system, which includes macroglobulin family proteins (alpha-2-macroglobulin, alpha-2-glycoprotein, pregnancy associated plasma protein A), their receptors (LRP, grp78), ligands (proteinases, cytokines, hormones, lipids, et al.) transforming and transcriptional factors for regulation of macroglobulins synthesis. After reviewing the functions of macroglobulin signaling system, and mechanisms of their realization, we discuss the complex and significant role of this system in different physiological and pathological processes.
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Reference: Zorin N.A., Zorina V.N., Macroglobulin signaling system, Biomeditsinskaya khimiya, 2012, vol: 58(4), 400-410.
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