Peculiarities of the circulating phagocytes functional activityin patients with different forms of drug-resistant pulmonary tuberculosis

   


1. Research Institute of Phtysiopulmonology
Type: Experimental/clinical study
DOI: 10.18097/pbmc20125804467      UDK: 616.24-002.5:615.015.8]:612.112.3      PubMed Id: 23413691
Year: 2012 vol: 58  issue:4  pages: 467-474
Abstract: Functional activity of circulating phagocytes (macrophages - Ms and neutrophils - Ns) was studied in 30 patients with infiltrative (I) and 30 patients with fibro-cavernous (FC) pulmonary tuberculosis (PT). Difference of the functional activity of both types of cells depending on the PT form was revealed: more significant increase in the oxygen-depending activity in FCPT while bactericide potential estimated with a zymosane induced NST-test was more pronounced in IPT patients. These data correlate with the blood levels of neopterin and elastase, the markers of the M and N activity, respectively. Participation of intracellular ADA in realization of oxygen-depending processes was demonstrated. Results of the multivariant analysis of the whole complex of the studied phagocyte characteristics, reflect their different roles in ther pathological process a prevailing role of Ms in the firstly diagnosed acute tuberculosis process (IPT) and Ns in the chronic progressive process (FCT).
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Reference: Titarenko O.T., Dyakova M.E., Esmedlyaeva D.S., Pavlova M.V., Yielkin A.V., Alekseeva N.C., Bondarenko B.B., Peculiarities of the circulating phagocytes functional activityin patients with different forms of drug-resistant pulmonary tuberculosis, Biomeditsinskaya khimiya, 2012, vol: 58(4), 467-474.
This paper is also available as the English translation:10.1134/S1990750811030152
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