The antiradical activity of plant extracts and healthful preventive combinations of these exrtacts with the phospholipid complex

   


1. Orekhovich Institute of Biomedical Chemistry, Russian Medical Academy of Sciences
2. Semenov Institute of Chemical Physics, Russian Academy of Sciences
3. Moscow State University of Technique and Control
Type: Experimental/clinical study
DOI: 10.18097/pbmc20125806712      UDK: 541.127      PubMed Id: 23350203
Year: 2012 vol: 58  issue:6  pages: 712-726
Abstract: Using the chemiluminescence method, the effective concentration of antioxidants (AO) and its reactivity toward peroxyl radicals (ARA, the k7 constant) have been measured for 13 plant extracts. In fact all extracts demonstrated ARA higher than ionol. Larix dahurica, Hypericum perforatum, Potentilla fruticosa, Aronia melanocarpa and Rhaponticum carthamoides extracts showed the highest values of ARA. The combinations Aronia + Raponticum extracts; Larix + Hibiscus extracts; Schizandra +Aronia extracts were synergistic (the synergism effect β of 38%, 33% and 22%). Apparently this phenomenon is the result of the synergistic interaction between compounds present in plant extracts. The Phospholipid complex - Lipoid S40, lacting any antioxidant effect alone, showed a potent synergistic effect with Aronia extract (β = 60%), Silybum extract (β = 41%). Clinical trials demonstrated, that combinations "Lipoid + Aronia extract", "Lipoid + Larix extract + Hibiscus extract", "Lipoid + Silybum extract", "Lipoid + Q10 + Rosa majalis extract" may be used as an additional component in the medicinal treatment, or as an individual prophylactic agent.
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Reference: Baranova V.S., Rusina I.F., Guseva D.A., Prozorovskaya N.N., Ipatova O.M., Kasaikina O.T., The antiradical activity of plant extracts and healthful preventive combinations of these exrtacts with the phospholipid complex, Biomeditsinskaya khimiya, 2012, vol: 58(6), 712-726.
This paper is also available as the English translation:10.1134/S1990750813020030
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