Oxidised dextrans influence on reactive oxygen species generation by murine peritoneal exudate phagocytic cells

   


1. Research Center of Clinical and Experimental Medicine Siberian Branch of Russian Academy of Medical Sciences
Type: Experimental/clinical study
DOI: 10.18097/pbmc20135901081      UDK: 577.124; 615.015.44; 616.011.5      PubMed Id: 23650725
Year: 2013 vol: 59  issue:1  pages: 81-89
Abstract: The effects of oxidized dextrans of different molecular weight on reactive oxygen species production and transmembrane mitochondrial potential of macrophages and neutrophils have been studied in vivo and in vitro . Oxidised dextrans demonstrated moderate direct antioxidant ability but induced intracellular oxidative stress through the increase of oxygen radical generation. This effect of the investigated compounds amplifies the cytotoxic and bactericidal potential of phagocytes and can influence isoniazid metabolism, thus increasing its efficiency in therapy of infectious diseases.
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Reference: Tkachev V.O., Zaikovskaya M.V., Troitsky A.V., Luzgina N.G., Shkurupy V.A., Oxidised dextrans influence on reactive oxygen species generation by murine peritoneal exudate phagocytic cells, Biomeditsinskaya khimiya, 2013, vol: 59(1), 81-89.
This paper is also available as the English translation:10.1134/S199075081202014X
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