The effect of berberine administration of evaluation of the functional state of rat liver after ligation of common bile duct

   


1. Institute of Pharmacology and Biochemistry, National Academy of Sciences of Belarus
Type: Experimental/clinical study
DOI: 10.18097/pbmc20135901090      UDK: 615.362:577      PubMed Id: 23650726
Year: 2013 vol: 59  issue:1  pages: 90-96
Abstract: On the eighth day after ligation of the common bile duct in rats a significant increase in the serum content of total lipids, cholesterol bilirubin and ALT, alkaline phosphatase, and gamma-glutamyltransferase was observed. In the microsomal fraction there was a marked decrease in the content and activity of microsomal monooxygenases. Introperitoneal injection of berberine (10 mg/kg) for 6 days caused a partial normalization of permeability of hepatocytes plasma membranes and activity of microsomal flavin-containing monooxygenases. It is suggested that berberine is a substrate and inducer of flavin-containing monooxygenases. Membrane-stabilizing effect of berberine is probably realized at the level of inhibition of prooxidant status of liver cells.
Download PDF:
Reference: Zverinsky I.V., Melnichenko N.G., Poplavsky V.A., Sutko I.P., Telegin P.G., Shlyahtun A.G., The effect of berberine administration of evaluation of the functional state of rat liver after ligation of common bile duct, Biomeditsinskaya khimiya, 2013, vol: 59(1), 90-96.
Bibliography
 2016(Vol:62)
 2015(Vol:61)
 2014(Vol:60)
 2013(Vol:59)
 2012(Vol:58)
 2011(Vol:57)
 2010(Vol:56)
 2009(Vol:55)
 2008(Vol:54)
 2007(Vol:53)
 2006(Vol:52)
 2005(Vol:51)
 2004(Vol:50)
 2003(Vol:49)