Apoptosis-reactivating agents for targeted anticancer therapy


1. R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine
Type: Review
DOI: 10.18097/pbmc20135902119      UDK: 615.357.631:577.611      PubMed Id: 23789342
Year: 2013 vol: 59  issue:2  pages: 119-143
Abstract: The current knowledge on molecular mechanisms of apoptosis is presented focusing on the key elements of the extrinsic death receptor pathway as well as the intrinsic mitochondrial pathway. Disregulation of apoptotic pathways is considered as a key factor in the survival of cancer cells in response to conventional chemotherapeutic drugs or radiation therapy. Substances that selectively reactivate apoptosis in malignant cells are the promising candidate anticancer drugs, which have now entered various phases of clinical trials. The up-to-date techniques allowing for non-invasive in vivo visualization of apoptotic cells with special reference to therapy-induced cell death are briefly surveyed.
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Reference: Philchenkov A.A., Apoptosis-reactivating agents for targeted anticancer therapy, Biomeditsinskaya khimiya, 2013, vol: 59(2), 119-143.
This paper is also available as the English translation:10.1134/S1990750812030043
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