Photo-activity of actinomycins

   


1. Institute of Cell Biophysics
Type: Experimental/clinical study
DOI: 10.18097/pbmc20135903349      UDK: 577.336      PubMed Id: 23987072
Year: 2013 vol: 59  issue:3  pages: 349-357
Abstract: Using actinomycins as an example, the possibility of increasing the anti-tumor activity of heterocyclic antibiotics due to photo-activation, has been studied. In model experiments with solutions of actinomycins, it was showed that actinomycins have a significant photochemical activity (of its own), changing by the binding to DNA in solution or in tumor cells. Photo-destruction of HeLa cells and the release of the antibiotic were observed.
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Reference: Vekshin N.L., Photo-activity of actinomycins, Biomeditsinskaya khimiya, 2013, vol: 59(3), 349-357.
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