Oxidative stress in the of alcoholic liver disease


1. Institute of General Pathology and Pathophysiology of Russian Academy of Medical Sciences
2. National Scientific Center of Drug Addiction
3. Russian University of Peoples Friendship
Type: Experimental/clinical study
DOI: 10.18097/pbmc20135904452      UDK: 577.3; 612.123; 612.393.1      PubMed Id: 24502143
Year: 2013 vol: 59  issue:4  pages: 452-458
Abstract: Parameters reflecting oxidative stress (OS) have been studied in 37 patients with alcoholic liver disease (ALD) during admission to the hospital and 2 weeks after the beginning of therapy. The patients were divided into 3 groups: alcoholic hepatitis (AH), alcoholic cirrhosis with hepatic insufficiency (the group C with Child-Paquet) and terminal stage patients (they subsequently died). All patients were characterized by a significant increase in plasma products of lipid peroxidation (conjugated diene and malondialdehyde) and decrease of the ceruloplasmin level. The coefficient K OS significantly exceeded normal values both on admission and after the 2-week course of traditional treatment. This suggests an important role of the OS with ALD.
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Reference: Panchenko L.F., Davydov B.V., Terebilina N.N., Baronets V.Yu., Zhuravleva A.S., Oxidative stress in the of alcoholic liver disease, Biomeditsinskaya khimiya, 2013, vol: 59(4), 452-458.
This paper is also available as the English translation:10.1134/S1990750814010120
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