1. ANO “Institute of Biomedical Problems” 2. ANO “Institute of Biomedical Problems”; Lomonosov Moscow State University 3. Central Clinic Hospital of Civil Aviation 4. Russian Children’s Clinical Hospital 5. ANO “Institute of Biomedical Problems”; Research Institute of Human Morphology of the Russian Academy of Medical Sciences
Abstract: Proinsulin content was measured in the serum of 82 children (aged from 3 to 14 years) with type 1 diabetes mellitus of various duration. Three groups of patients characterized by low (54%), normal (42%) and high (4%) levels of this prohormone were recognized. No dependence the proinsulin level on the disease term was found. The serum proinsulin level may be used as a parameter specifying the pathogenesis of type 1 diabetes mellitus.
Reference: Lotosh N.Y., Selishcheva A.A., Nadorov S.A., Badyshtov B.A., Volkov I.E., Saveljev S.V., The proinsulin level in the blood of children with type 1 diabetes mellitus of various duration, Biomeditsinskaya khimiya, 2013, vol: