The proinsulin level in the blood of children with type 1 diabetes mellitus of various duration

   


1. ANO “Institute of Biomedical Problems”
2. ANO “Institute of Biomedical Problems”; Lomonosov Moscow State University
3. Central Clinic Hospital of Civil Aviation
4. Russian Children’s Clinical Hospital
5. ANO “Institute of Biomedical Problems”; Research Institute of Human Morphology of the Russian Academy of Medical Sciences
Type: Experimental/clinical study
DOI: 10.18097/pbmc20135905563      UDK: 616.379-008.64      PubMed Id: 24479346
Year: 2013 vol: 59  issue:5  pages: 563-569
Abstract: Proinsulin content was measured in the serum of 82 children (aged from 3 to 14 years) with type 1 diabetes mellitus of various duration. Three groups of patients characterized by low (54%), normal (42%) and high (4%) levels of this prohormone were recognized. No dependence the proinsulin level on the disease term was found. The serum proinsulin level may be used as a parameter specifying the pathogenesis of type 1 diabetes mellitus.
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Reference: Lotosh N.Y., Selishcheva A.A., Nadorov S.A., Badyshtov B.A., Volkov I.E., Saveljev S.V., The proinsulin level in the blood of children with type 1 diabetes mellitus of various duration, Biomeditsinskaya khimiya, 2013, vol: 59(5), 563-569.
This paper is also available as the English translation:10.1134/S1990750812030080
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