The dose-dependent influence of 3,5-dicarbometoxyphenilbiguanidе on activity of the glutathione antioxidant system in heart and blood serum of rats with the experimental myocardial infarction

   


1. Voronezh State University
Type: Experimental/clinical study
DOI: 10.18097/pbmc20135906655      UDK: 57.021      PubMed Id: 24511677
Year: 2013 vol: 59  issue:6  pages: 655-661
Abstract: Administration of a synthetic compound with predicted anti-ischemic and cardioprotective activity, 3,5-dicarbometoxyphenilbiguanidе, - to rats with experimental myocardial infarction led to a decrease in the lipid peroxidation level, glutathione peroxidase activity, the level of reduced glutathione, activity of NADP-isocitrate dehydrogenase in the heart and blood serum, and also activity of glucoso-6-phosphate dehydrogenase in heart in comparison with their levels in untreated animals with myocardial infarction. This may be attributed to a decrease of free radical processes and reduction of antioxidant system loading. At the same time the increase glutathione reductase activity observed under these conditions in the heart and and blood serum probably associated with specific influence of 3,5-dicarbometoxyphenilbiguanidе on this enzyme.
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Reference: Tanygina E.S., Popova T.N., Semenikhina A.V., Matasova L.V., Kryl'skiy E.D., The dose-dependent influence of 3,5-dicarbometoxyphenilbiguanidе on activity of the glutathione antioxidant system in heart and blood serum of rats with the experimental myocardial infarction, Biomeditsinskaya khimiya, 2013, vol: 59(6), 655-661.
This paper is also available as the English translation:10.1134/S1990750812040099
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