Functional activity of NADH-dependent reductase system in liver and guerin’s carcinoma microsomal fraction in rats exposed to preliminary irradiation

   


1. Fedkovich Chernovtsy National University
Type: Experimental/clinical study
DOI: 10.18097/pbmc20135906662      UDK: 577.112+616-006.6      PubMed Id: 24511678
Year: 2013 vol: 59  issue:6  pages: 662-672
Abstract: The activity of liver and Guerin’s carcinoma microsomal NADH-dependent reductase system has been investigated in tumor-bearing rats exposed to preliminary irradiation. Preliminary irradiation of rats (before transplantation of Guerin’s carcinoma) resulted in the decrease of NADH-cytochrome b reductase activity and contents of cytochrome b in the Guerin’s carcinoma microsomal fraction in the logarithmic phases of oncogenesis compared with the non-irradiated tumor-bearing rats. The effect of irradiation preceding transplantation of the tumor to rats results in the increase of enzymatic activities of liver microsomal NADH-cytochrome b reductase in the latent and logarithmic phases of tumor growth as compared with non-irradiated tumor-bearing rats. At the same time the contents of cytochrome b decreases. During longer periods after irradiation the investigated parameters approached to those in the group of non-irradiated tumor-bearing animals.
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Reference: Marchenko M.M., Ketsa O.V., Functional activity of NADH-dependent reductase system in liver and guerin’s carcinoma microsomal fraction in rats exposed to preliminary irradiation, Biomeditsinskaya khimiya, 2013, vol: 59(6), 662-672.
This paper is also available as the English translation:10.1134/S1990750812040063
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