Some peculiarities in the manifestation of oxidative stress and current status of antioxidant system in adolescents of different age groups with obesity, complicated by insulin resistance and without it

   


1. Institute of Children and Adolescents Health Care of NAMS of Ukraine
Type: Experimental/clinical study
DOI: 10.18097/PBMC20146002264      UDK: 616.39-053.6:577.15+612.349.8      PubMed Id: 24837315
Year: 2014 vol: 60  issue:2  pages: 264-274
Abstract: The study has shown that neuroendocrine obesity in adolescents is associated with the formation of oxidative stress which is more pronounced in early than in late puberty. Obesity with concomitant insulin resistance increases manifestations of oxidative stress accompanied by a compensatory increase in the activity of catabolic enzymes and reduced capacity of the defense antioxidant system in late puberty. These alterations may be caused by age-related changes in hormonal secretion under conditions of insulin resistance in late puberty.
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Reference: Kulieshova D.K., Davydov V.V., Some peculiarities in the manifestation of oxidative stress and current status of antioxidant system in adolescents of different age groups with obesity, complicated by insulin resistance and without it, Biomeditsinskaya khimiya, 2014, vol: 60(2), 264-274.
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