Introduction of mutations in insulin molecule: positive and negative mutations

   


1. Saint Petersburg State University, Department of Biology
Type: Review
DOI: 10.18097/pbmc20146004430      UDK: 577.171.7      PubMed Id: 25249526
Year: 2014 vol: 60  issue:4  pages: 430-437
Abstract: Introduction of mutations in an insulin molecule is one of the important approaches to drug development for treatment of diabetes mellitus. Generally, usage of mutations is aimed at activation of insulin and insulin receptor interaction. Such mutations can be considered as positive. Mutations that reduce the binding efficacy are negative. There are neutral mutations as well. This article considers both natural mutations that are typical for various members of the insulin superfamily and artificial ones which are introduced to improve the insulin pharmacological characteristics. Data presented here can be useful in developing new effective insulin analogues for treatment of diabetes mellitus.
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Reference: Ksenofontova O.I., Introduction of mutations in insulin molecule: positive and negative mutations, Biomeditsinskaya khimiya, 2014, vol: 60(4), 430-437.
This paper is also available as the English translation:10.1134/S1990750813040045
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