Effect of melaxen and valdoxan on free radical processes intensity, aconitate hydratase activity and citrate content in rats tissues under hyperthyroidism

   


1. Voronezh State University, Biology and Soil Science Faculty, Department of Medical Biochemistry and Microbiology
2. Burdenko Voronezh State Medical Academy
Type: Experimental study
DOI: 10.18097/pbmc20146004462      UDK: 576.32/.36:616.441      PubMed Id: 25249529
Year: 2014 vol: 60  issue:4  pages: 462-468
Abstract: The influence of melaxen and valdoxan on the biochemiluminescence parameters, aconitate hydratase activity and citrate level in rats heart and liver during development of experimental hyperthyroidism has been investigated. Administration of these substances promoted a decrease of biochemiluminescence parameters, which had been increased in tissues of rats in response to the development of oxidative stress under hyperthyroidism. Aconitate hydratase activity and citrate concentration in rats liver and heart, growing at pathological conditions, changed towards control value after administration of the drugs correcting melatonin level. The results indicate the positive effect of valdoxan and melaxen on oxidative status of the organism under the development of experimental hyperthyroidism that is associated with antioxidant action of melatonin.
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Reference: Gorbenko M.V., Popova T.N., Shulgin K.K., Popov S.S., Agarkov A.A., Effect of melaxen and valdoxan on free radical processes intensity, aconitate hydratase activity and citrate content in rats tissues under hyperthyroidism, Biomeditsinskaya khimiya, 2014, vol: 60(4), 462-468.
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