Abstract: The influence of a single injection of haloperidol on basic carboxypeptidases (biologically active peptide processing enzymes) activity in rat tissues was studied. Acute exposure to haloperidol increased the activity of carboxypeptidases H (CP H) in hypothalamic-pituitary-adrenal system and cerebellum and reduced such activity in testes. Multidirectional changes of PMSF-inhibited carboxypeptidases activity (PMSF-CP) were observed after a single haloperidol injection in all studied tissues except testes. It is suggested that changes of CP H and PMSF-CP activity might affect levels of regulatory peptides in the brain and blood and thus may be involved in general and side effects of haloperidol on the organism.
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Reference: Pravosudova N.A., Bykova I.O., Comparison of basic carboxypeptidases activity in male rats tissues at a single injection of haloperidol, Biomeditsinskaya khimiya, 2014, vol: 60(5), 548-552.
4. Генгин М.Т. (2002) Особенности структурно функциональной организации и физико- химические свойства нелизосомальных пептидгидролаз мозга животных. Дисс. докт. наук, Российский университет дружбы народов, Москва. Scholar google search
5. Fricker L.D., Snyder S.H. (1983) J. Biol. Chem., 258, 10950-10955. Scholar google search
6. Lowry O.H., Rosebrough N.J., Farr A.G., Randall R.J. (1951) J. Biol. Chem., 193, 265-275. Scholar google search
7. Chen C.L., Dionne F.T., Roberts J.L. (1983) Proc. Natl. Acad. Sci. USA., 80(8), 2211-2215. CrossRef Scholar google search
9. Коста Е., Фратта В., Хонг Дж.С., Морони Ф., Янг Х.-Ю.Т. (1981) в кн.: Эндорфины. Мир, Москва, сс. 217-227. Scholar google search
10. Rocca P., Bellone G., Benna P., Bergamaso B., Ravizza L., Ferrero P. (1993) J. Immunopharmacol., 25, 163-178. CrossRef Scholar google search
11. Салдаев Д.А. (2001) Активность основных карбоксипептидаз в тканях мышей при введении тестостерона и прогестерона. Автореф. дисс. канд. наук, Санкт-Петербургский государственный университет, Санкт-Петербург. Scholar google search
12. Pillot C., Ortiz J., Héron A., Ridray S., Schwartz J.C., Arrang J.M. (2002) J. Neurosci., 22, 7272-7280. Scholar google search
