Effect of sulfated polysaccharides from brown seaweed laminaria japonica on the morfology of lymfoid organs and functional characteristics of immunocompetent cells

   


1. Acad. E.A. Wagner Perm State Medical Academy MH RF
2. Somov Scientific Research Institute of Epidemiology and Microbiology
3. Mechnikov Scientific Research Institute of vaccines and sera
4. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS
Type: Experimental study
DOI: 10.18097/pbmc20146005581      UDK: 615.37:567.5[57.062:571.27]:567.7[575.87]:577.114.5      PubMed Id: 25386888
Year: 2014 vol: 60  issue:5  pages: 581-590
Abstract: The effect of sulfated polysaccharide fucoidan from the brown alga Laminaria japonica on morphological characteristics of mouse lymphoid organs, subpopulations of spleen mononuclear leukocytes, cytokine production and cytotoxic activity of splenocytes has been investigated. Fucoidan promoted activation and proliferation of lymphoid hematopoietic cells in primary and secondary immunogenesis bodies, increased expression of markers CD19, NK, NKT, CD25, MHC II, TCR, TLR2 and TLR4, the cytotoxic activity of splenocytes and production of immunoregulatory and proinflammatory cytokines (IL- 2, IL-12, IFN-g, TNF-a, IL-6). This suggests activation of effector mechanisms of innate immunity and adaptive immune responses via the Th-1 type.
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Reference: Lebedynskaya E.A., Makarenkova I.D., Lebedynskaya O.V., Akhmatova N.K., Zvyagintseva T.N., Effect of sulfated polysaccharides from brown seaweed laminaria japonica on the morfology of lymfoid organs and functional characteristics of immunocompetent cells, Biomeditsinskaya khimiya, 2014, vol: 60(5), 581-590.
This paper is also available as the English translation:10.1134/S1990750815010060
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