The state of the mitochondrial energy-supplying system of blood leukocytes in the dynamics of guerin's carcinoma growth under the low-level irradiation conditions

   


1. Yurii Fedkovych Chernovtsi National University
Type: Experimental study
DOI: 10.18097/PBMC20146006631      UDK: 591.111.1.-112.4:616-006.6      PubMed Id: 25552501
Year: 2014 vol: 60  issue:6  pages: 631-635
Abstract: Mitochondrial NADH-dehydrogenase, succinate dehydrogenase and cytochrome oxidase activities of peripheral blood leukocytes of rats with the grafted Guerin's carcinoma were studied in the dynamics of oncogenesis under the conditions of the preliminary low-level irradiation. Tumor growth was accompanied by a decrease in NADH-dehydrogenase activity, an increase of succinate dehydrogenase activity. Cytochrome oxidase activity of leucocytes remained at the control level up to the terminal stages of tumor growth. Preliminary low-level irradiation of the tumor bearing animals caused a tendency to the decrease of enzymatic activities studied. This tendency was observed from the initial stages of oncogenesis.
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Reference: Marchenko M.M., Voloshchuk O.N., The state of the mitochondrial energy-supplying system of blood leukocytes in the dynamics of guerin's carcinoma growth under the low-level irradiation conditions, Biomeditsinskaya khimiya, 2014, vol: 60(6), 631-635.
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